Marc Fontecave is Professor at the Collège de France (Paris) and member of the French Academy of Sciences. He is also Director of the Laboratory of Chemistry of Biological Processes (CNRS, Collège de France, Université P&M. Curie) and heads the group Biocatalysis of the Laboratory of Chemistry and Biology of Metals (CNRS, CEA, Université J. Fourier) in Grenoble, France.
Marc Fontecave present research activity is aimed at understanding the molecular structure and the chemical reactivity of complex redox biological systems containing metal ions, in particular iron. These issues are tackled through a multidisciplinary approach based on the concepts and methods of protein chemistry, enzymology, molecular and structural biology on the one hand, and synthetic organic and inorganic chemistry on the other hand, as well as on the utilization of a variety of spectroscopic tools.
Examples of research projects under current investigation:
- characterisation of iron-sulfur enzymes involved in the modification of biological macromolecules with special emphasis on protein and tRNA modification and DNA repair;
- characterisation of the protein machineries involved in the complex biosynthetic process of metallocofactors (hydrogenases, iron sulfur enzymes);
- characterisation of biosynthetic pathways of important biological cofactors (NADH, ubiquinone, biotin, …) with medical and biotechnological applications;
- preparation, evaluation and development of novel bioinspired (photo) catalysts based on non noble metals for hydrogen production and oxidation as well as for carbon dioxide reduction and their development in fuel cells and (photo) electrolyzers.